Sleepy Time
As a long-time insomniac, I have tried every prescription, over-the-counter, mail order remedy I can find. I have a drawer of things that didn't work, including those that actually made me jittery and anxious rather than relaxed.
And from conversations I've had with just about every group I've been a part of lately, I am not alone.
The Magic Pill
Our brains are constantly making predictions based on our concepts and past experience to interpret the pleasant and unpleasant sensations in our bodies. The feedback from the body (in the form of sensation) about how the physical systems are working is called interoception -- being aware of the internal world.
Those concepts and guesses are how we make sense of sensation so we know what caused the sensation and what to do about it. More intense sensations are used to make emotions; less intense sensations are used to make thoughts and beliefs.